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Treatment with an immune checkpoint inhibitor ICI , especially nivolumab, was associated with a rare but increased risk of tuberculosis or atypical mycobacterial infection, which sometimes led to death, found a retrospective analysis published in ESMO Open. All cases were reported between January 1, , and March 31, Overall, 72 reported cases of tuberculosis were identified, of which 45 The remaining cases were attributed to atezolizumab 6. In addition, 13 reported cases of atypical mycobacterial infection were identified, of which 9 The remaining cases were attributed to atezolizumab 7. Continue Reading. No reported cases of tuberculosis or atypical mycobacterial infection were attributed to avelumab. These findings translated to significantly higher risk of developing tuberculosis reporting odds ratio [ROR], 1.

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